The Role of Alveolar Epithelial Type II-Like Cells in Uptake of Structurally Different Antigens and in Polarisation of Local Immune Responses

0444678 - MBÚ 2016 RIV US eng J - Článek v odborném periodiku
Akgün, J. - Schabussova, I. - Schwarzer, Martin - Kozáková, Hana - Kundi, M. - Wiedermann, U.
The Role of Alveolar Epithelial Type II-Like Cells in Uptake of Structurally Different Antigens and in Polarisation of Local Immune Responses.
PLoS ONE. Roč. 10, č. 4 (2015). ISSN 1932-6203. E-ISSN 1932-6203
Institucionální podpora: RVO:61388971
Klíčová slova: BIRCH POLLEN ALLERGEN * DENDRITIC CELLS * AIRWAY INFLAMMATION
Kód oboru RIV: EC - Imunologie
Impakt faktor: 3.057, rok: 2015

Our previous studies on intranasal tolerance induction demonstrated reduction of allergic responses with different allergen constructs. The underlying mechanisms varied depending on their conformation or size. Both antigens were taken up preferably by ATII-like cells (ATII-LCs) in naive mice, and by macrophages in sensitised mice. After intranasal application, Bv1-Peptide was taken up faster and more efficiently than Bv1-Protein. In vivo and in vitro experiments revealed that Bv1-Protein induced the transcription of thymic stromal lymphopoietin mRNA while Bv1-Peptide induced the transcription of IL-10 and MCP1 mRNA in ATII-LCs.
Trvalý link: http://hdl.handle.net/11104/0247202