Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate

0444432 - FGÚ 2016 RIV GB eng J - Článek v odborném periodiku
Posadowska, U. - Pařízek, Martin - Filová, Elena - Wlodarczyk-Biegun, M. - Kamperman, M. - Bačáková, Lucie - Pamula, E.
Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate.
International Journal of Pharmaceutics. Roč. 485, 1-2 (2015), s. 31-40. ISSN 0378-5173. E-ISSN 1873-3476
Grant CEP: GA MZd(CZ) NT13297
Institucionální podpora: RVO:67985823
Klíčová slova: sodium alendronate * PLGA * nanoparticles
Kód oboru RIV: EI - Biotechnologie a bionika
Impakt faktor: 3.994, rok: 2015

Our system based on Aln-loaded PLGA nanoparticles suspended in gellan gum hydrogel matrix: (i) was found to be injectable and restored its elastic structure after extrusion, (ii) assured local and uniform drug delivery, and (iii) inhibited osteoclasts differentiation without affecting osteoblasts functions. The results show the potential of our approach for the local treatment of osteoporosis and other bone tissue pathologies
Trvalý link: http://hdl.handle.net/11104/0246952