Počet záznamů: 1
Stem cells regenerative properties on new rat spinal fusion model
- 1.0444382 - FGÚ 2016 RIV CZ eng J - Článek v odborném periodiku
Klíma, K. - Vaněček, Václav - Kohout, A. - Jiroušek, Ondřej - Foltán, R. - Štulík, J. - Machoň, V. - Pavlíková, G. - Jendelová, Pavla - Syková, Eva - Šedý, Jiří
Stem cells regenerative properties on new rat spinal fusion model.
Physiological Research. Roč. 64, č. 1 (2015), s. 119-128. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA MZd(CZ) NT13477; GA ČR(CZ) GAP304/10/0320
Institucionální podpora: RVO:67985823 ; RVO:68378297 ; RVO:68378041
Klíčová slova: mesenchymal stem cells * bone graft substitute * spinal fusion
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 1.643, rok: 2015
The purpose of this study was to establish a simple model of spinal fusion based on a rat model including verification of the possible use of titanium microplates with hydroxyapatite scaffold combined with human bone marrow-derived mesenchymal stem cells (MSCs). The new model of interspinous fusion was safe, easy, inexpensive, with zero mortality. We did not detect any substantial pathological changes or tumor formation after graft implantation. In the group with MSCs we described minor inflamatory response which indicates the imunomodulational and antiinflamatory role of MSCs
Trvalý link: http://hdl.handle.net/11104/0246919
Počet záznamů: 1