Preserved cardiac mitochondrial function and reduced ischaemia/reperfusion injury afforded by chronic continuous hypoxia: Role of opioid receptors

0444243 - FGÚ 2016 RIV AU eng J - Článek v odborném periodiku
Maslov, L. N. - Naryzhnaya, N. V. - Prokudina, E. S. - Kolář, František - Gorbunov, A. S. - Zhang, Y. - Wang, H. - Tsibulnikov, S.Yu. - Portnichenko, A. G. - Lasukova, T. V. - Lishmanov, Yu. B.
Preserved cardiac mitochondrial function and reduced ischaemia/reperfusion injury afforded by chronic continuous hypoxia: Role of opioid receptors.
Clinical and Experimental Pharmacology and Physiology. Roč. 42, č. 5 (2015), s. 496-501. ISSN 0305-1870. E-ISSN 1440-1681
Grant CEP: GA ČR(CZ) GAP303/12/1162
Institucionální podpora: RVO:67985823
Klíčová slova: cardioprotection * chronic hypoxia * ischaemia/reperfusion * mitochondrial function * opioid receptors
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 2.004, rok: 2015

Adaptation of rats to chronic continuous hypoxia protected their hearts against post-ischemic contractile dysfunction, decreased creatine kinase release and attenuated the depression of mitochondrial respiration and calcium retention capacity. All these beneficial effects were abolished by naloxone. It suggests that the preserved mitochondrial function contributes to the protected cardiac phenotype conferred by chronic hypoxia and points to an important role of opioid receptor activation
Trvalý link: http://hdl.handle.net/11104/0246809