Activation of either the ETA or the ETB receptors is involved in the development of electrographic seizures following intrahippocampal infusion of the endothelin-1 in immature rats

0443220 - FGÚ 2016 RIV US eng J - Článek v odborném periodiku
Tsenov, Grygoriy - Vondráková, Kateřina - Otáhal, Jakub - Burchfiel, J. - Kubová, Hana
Activation of either the ETA or the ETB receptors is involved in the development of electrographic seizures following intrahippocampal infusion of the endothelin-1 in immature rats.
Experimental Neurology. Roč. 265, Mar 2015 (2015), s. 40-47. ISSN 0014-4886. E-ISSN 1090-2430
Grant CEP: GA ČR(CZ) GPP304/11/P386; GA ČR(CZ) GBP304/12/G069; GA ČR(CZ) GA14-20613S
Institucionální podpora: RVO:67985823
Klíčová slova: focal ischemia * endothelin-1 * cerebral blood flow * oxygen saturation * seizures * hippocampus * immature rat * ET receptors
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 4.657, rok: 2015

The activation of ETA receptors is crucial for ischemia development, however either ETA or ETB receptors mediate the development of seizures following the application of ET-1 in immature rats. The dissociation between the ischemic-producing and seizure-producing processes suggests that damage is not necessary to induce seizures, although it may exacerbate them
Trvalý link: http://hdl.handle.net/11104/0245968