Melatonin administered during the fetal stage affects circadian clock in the suprachiasmatic nucleus but not in the liver

0443146 - FGÚ 2016 RIV US eng J - Článek v odborném periodiku
Houdek, Pavel - Polidarová, Lenka - Nováková, Marta - Matějů, Kristýna - Kubík, Štěpán - Sumová, Alena
Melatonin administered during the fetal stage affects circadian clock in the suprachiasmatic nucleus but not in the liver.
Developmental Neurobiology. Roč. 75, č. 2 (2015), s. 131-144. ISSN 1932-8451. E-ISSN 1932-846X
Grant CEP: GA ČR(CZ) GAP303/12/1108
Institucionální podpora: RVO:67985823
Klíčová slova: ontogenesis * circadian system * suprachiasmatic nuclei * clock gene * melatonin
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 2.529, rok: 2015

The aim of the study was to ascertain the role of maternal melatonin in entrainment of the fetal circadian clocks. The role of maternal melatonin in the entrainment of fetal circadian clocks has been suggested, but direct evidence was lacking. The data demonstrate that in pregnant rats with suppressed endogenous melatonin levels, application of melatonin affects the fetal clock in the SCN but not in the liver
Trvalý link: http://hdl.handle.net/11104/0245901