Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin

0443023 - ÚMCH 2016 RIV GB eng J - Článek v odborném periodiku
Fang, J. - Liao, L. - Yin, H. - Nakamura, H. - Šubr, Vladimír - Ulbrich, Karel - Maeda, H.
Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin.
Future Science OA. Roč. 2015, č. 4 (2015), s. 1-13. ISSN 2056-5623
Grant CEP: GA ČR(CZ) GAP301/12/1254
Grant ostatní: AV ČR(CZ) AP0802
Program: Akademická prémie - Praemium Academiae
Institucionální podpora: RVO:61389013
Klíčová slova: fluorescent nanoprobe * photodynamic therapy * theranostic nanomedicine
Kód oboru RIV: CD - Makromolekulární chemie

To evaluate the potential of tumor-targeted nanoprobe, N-(2-hydroxypropyl)methacrylamide copolymer-conjugated zinc protoporphyrin (PZP) for photodynamic therapy (PDT) and tumor imaging. Different tumor models including carcinogen-induced cancer were used, PZP was intravenously injected followed by irradiation with xenon or blue fluorescent light on tumor. One PZP 20 mg/kg (ZnPP equivalent) dose with two or three treatments of light at an intensity of ≥20 J/cm2 caused necrosis and disappearance of most tumors (>70%) in different tumor models. We also confirmed PZP-based tumor imaging in carcinogen-induced breast tumor and colon cancer models. These findings support the potential application of PZP as a tumor-selective nanoprobe for PDT as well as tumor imaging, by virtue of the enhanced permeability and retention effect.
Trvalý link: http://hdl.handle.net/11104/0248228