Brain Extracellular Matrix in Health and Disease

0442656 - ÚEM 2015 RIV NL eng M - Část monografie knihy
Morawski, M. - Filippov, M. - Tzinia, A. - Tsilibary, E. - Vargová, Lýdia
ECM in brain aging and dementia.
Brain Extracellular Matrix in Health and Disease. Amsterdam: ELSEVIER SCIENCE BV, 2014 - (Dityatev, A. - WehrleHaller, B. - Pitkanen, A.), s. 207-227. ISBN 978-0-444-63486-3
Institucionální podpora: RVO:68378041
Klíčová slova: Alzheimer's disease * extracellular space * perineuronal nets
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy

As the extracellular matrix (ECM) and matrix metalloproteinases (MMPs) are important regulators of plasticity, learning, and memory, age-related changes in the ECM composition are major determinants of the onset and development of the brain neurodegenerative disorders. The role of ECM has largely a dual “face” where beneficial and deleterious effects prevail depending on the actual state of the tissue and more study is necessary to understand the diverse roles of these molecules
Trvalý link: http://hdl.handle.net/11104/0245467