Počet záznamů: 1
Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization
- 1.0442565 - ÚMG 2015 RIV DE eng J - Článek v odborném periodiku
Bříza, T. - Králová, Jarmila - Dolenský, B. - Rimpelová, S. - Kejík, Z. - Ruml, T. - Hajdúch, M. - Džubák, P. - Mikula, I. - Martásek, P. - Poučková, P. - Král, V.
Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization.
Chembiochem. Roč. 16, č. 4 (2015), s. 555-558. ISSN 1439-4227. E-ISSN 1439-7633
Grant CEP: GA MŠMT(CZ) CZ.1.05/2.1.00/01.0030; GA ČR(CZ) GAP303/11/1291; GA MŠMT(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:68378050
Klíčová slova: cancer * methinium salt * quinoxaline
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 2.850, rok: 2015
A novel pentamethinium salt was synthesized with an unforeseen expanded conjugated quinoxaline unit directly incorporated into a pentamethinium chain. The compound exhibited high fluorescence intensity, selective mitochondrial localization, high cytotoxicity, and selectivity toward malignant cell lines, and resulted in remarkable in vivo suppression of tumor growth in mice.
Trvalý link: http://hdl.handle.net/11104/0245367
Počet záznamů: 1