Role of HMGB Proteins in Chromatin Dynamics and Telomere Maintenance in Arabidopsis thaliana

0440863 - BFÚ 2015 RIV AE eng J - Článek v odborném periodiku
Schrumpfová, P. - Fojtová, Miloslava - Mokroš, P. - Grasser, K.D. - Fajkus, Jiří
Role of HMGB Proteins in Chromatin Dynamics and Telomere Maintenance in Arabidopsis thaliana.
Current Protein and Peptide Science. Roč. 12, č. 2 (2011), s. 105-111. ISSN 1389-2037. E-ISSN 1875-5550
Institucionální podpora: RVO:68081707
Klíčová slova: HMGB * telomere shortening/elongation * plants
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 2.886, rok: 2011

Chromosome stability is conditioned by functional chromatin structure of chromosome ends - telomeres. Organisation and regulation of telomere maintenance represent a complex process whose details still remain enigmatic, especially in plants. Several telomere-binding or telomere-associated proteins and distinct epigenetic marks have been shown to influence telomere length and telomerase activity. HMGB proteins play important role in dynamic changes of chromatin structure and are involved in regulation of cellular processes of key importance, such as replication, transcription, recombination and DNA-repair. HMGB proteins in plants are more diversified than in other eukaryotes. Here, we summarise the roles of plant HMGB proteins in regulation of chromatin structure and dynamics and report on the newly identified role of AtHMGB1 protein in the regulation of plant telomere length. Astonishingly, contrary to mice mHMGB1 homologue, AtHMGB1 does not affect telomerase activity and AtHMGB1 loss or overexpression does not cause any obvious changes in chromatin architecture.
Trvalý link: http://hdl.handle.net/11104/0243970