Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-epsilon-caprolactone nanofibers and growth factors for prevention of incisional hernia formation

0439596 - FGÚ 2015 RIV NZ eng J - Článek v odborném periodiku
Plencner, M. - East, B. - Tonar, Z. - Otáhal, M. - Prosecká, E. - Rampichová, M. - Krejčí, T. - Litvinec, Andrej - Buzgo, M. - Míčková, A. - Nečas, A. - Hoch, J. - Amler, E.
Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-epsilon-caprolactone nanofibers and growth factors for prevention of incisional hernia formation.
International Journal of Nanomedicine. Roč. 9, č. 2014 (2014), s. 3263-3227. E-ISSN 1178-2013
Institucionální podpora: RVO:67985823
Klíčová slova: nanofibers * growth factors * surgical mesh
Kód oboru RIV: FP - Ostatní lékařské obory
Impakt faktor: 4.383, rok: 2014

Incisional hernia affects up to 20% of patients after abdominal surgery. Currently used hernia repair meshes do not guarantee success but only extend the recurrence-free period by about 5 years. Electrospun nanofibers of various polymers have been used as tissue scaffolds, due to their low cost and good biocompatibility. We have tested a biodegradable polyester poly-e-caprolactone in the form of nanofibers as a scaffold for fascia healing in an abdominal closure reinforcement model for prevention of incisional hernia formation. Both in vitro tests and an experiment on a rabbit model have shown promising results
Trvalý link: http://hdl.handle.net/11104/0242839