Pyrimidine compounds inhibiting the formation of nitric oxide and prostaglandin E2, method of production thereof and use thereof

0438200 - ÚOCHB 2015 RIV eng P - Patentový dokument
Jansa, Petr - Holý, Antonín - Zídek, Zdeněk - Kmoníčková, Eva - Janeba, Zlatko
Pyrimidine compounds inhibiting the formation of nitric oxide and prostaglandin E2, method of production thereof and use thereof.
2014. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. - Ústav experimentální medicíny AV ČR, v. v. i. Datum udělení patentu: 11.11.2014. Číslo patentu: US8883798
Institucionální podpora: RVO:61388963 ; RVO:68378041
Klíčová slova: pyrimidine compounds * prostaglandin E2 * nitric oxide
Kód oboru RIV: CC - Organická chemie; FR - Farmakologie a lékárnická chemie (UEM-P)
http://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20141111&DB=EPODOC&locale=en_EP&CC=US&NR=8883798B2&KC=B2&ND=4

The invention provides pyrimidine compounds of general formula (I), which reduce simultaneously the production of nitric oxide (NO) and prostaglandin E2 (PGE2). They have no negative effect on the viability of cells in concentrations decreasing the production of these factors by up to 50%; they are not cytotoxic. Furthermore, a method of preparation of the pyrimidine compounds of general formula (I), carrying 2-formamido group, a pharmaceutical composition comprising the substituted pyrimidine compounds according to the invention, and the use of these compounds for the treatment of inflammatory and cancer diseases are provided.
Trvalý link: http://hdl.handle.net/11104/0241660