Formation of Cell-To-Cell Connection between Bone Marrow Cells and Isolated Rat Cardiomyocytes in a Cocultivation Model

0437439 - ÚT 2015 RIV US eng J - Článek v odborném periodiku
Skopalík, J. - Pásek, Michal - Rychtárik, M. - Koristek, Z. - Gabrielová, E. - Sheer, P. - Matejovič, P. - Modrianský, M. - Klabusay, M.
Formation of Cell-To-Cell Connection between Bone Marrow Cells and Isolated Rat Cardiomyocytes in a Cocultivation Model.
Journal of Cell Science and Therapy. Roč. 5, č. 5 (2014), s. 1000185. ISSN 2157-7013
Institucionální podpora: RVO:61388998
Klíčová slova: bone marrow * mononuclear cells * isolated cardiomyocytes * cocultivation
Kód oboru RIV: BO - Biofyzika
http://omicsonline.org/open-access/formation-of-celltocell-connection-between-bone-marrow-cells-and-isolated-rat-cardiomyocytes-2157-7013.1000185.php?aid=33364

Limited regenerative potential of cardiomyocytes (CMs) causes irreversible changes in heart tissue during pathological processes. However bone marrow mononuclear cells (BM-MNCs) can migrate to this tissue, incorporate to the area of dead or missing myocytes, and improve the global heart function. The mechanism of BMMSCs’ incorporation and interaction with CMs is not clear. Our aim was to create an in vitro model which would enable to study the interaction of BM-MNCs with CMs and to make a microscopy description of these interactions.
Trvalý link: http://hdl.handle.net/11104/0241385