Metallization of Single-Stranded Polyl by Zn2+ Ions in Neutral Solutions

0437094 - ÚOCHB 2015 RIV US eng J - Článek v odborném periodiku
Sorokin, V. A. - Valeev, V. A. - Usenko, E. L. - Andrushchenko, Valery
Metallization of Single-Stranded Polyl by Zn2+ Ions in Neutral Solutions.
Journal of Physical Chemistry B. Roč. 118, č. 43 (2014), s. 12360-12365. ISSN 1520-6106. E-ISSN 1520-5207
Institucionální podpora: RVO:61388963
Klíčová slova: nucleic acid metallization * zinc ion * differential UV spectroscopy
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
Impakt faktor: 3.302, rok: 2014

Metallization of single-stranded polyinosinic acid (polyI) by Zn2+ ions at pH 7.0 was studied by differential UV spectroscopy at different temperatures. It was found that polyI is metallized at N7 and N1 atoms of hypoxanthine. The concentration dependence of the degree of binding of Zn2+ ions to both N7 and N1 sites was obtained, and the corresponding binding constants were determined. Metallization of N1 occurs due to Zn2+ substituting the imino protons and is effective not only at alkaline but also at neutral pH. This makes multistranded polyI-based systems more promising candidates for use in nanoelectronics than natural DNA sequences, metallization of which can be achieved only at alkaline pH.
Trvalý link: http://hdl.handle.net/11104/0240893