CANCER-PAthological breakdown of coherent energy states

0436816 - ÚFE 2015 RIV SG eng J - Článek v odborném periodiku
Pokorný, Jiří - Pokorný, Jan - Kobilková, J. - Jandová, Anna - Vrba, J. - Vrba, J. jr. … celkem 7 autorů
CANCER-PAthological breakdown of coherent energy states.
Biophysical Reviews and Letters. Roč. 9, č. 1 (2014), s. 115-133. ISSN 1793-0480
Institucionální podpora: RVO:67985882 ; RVO:68378271
Klíčová slova: breakdown of coherent states * Cancer electrodynamics * Warburg effect
Kód oboru RIV: JA - Elektronika a optoelektronika, elektrotechnika; BO - Biofyzika (FZU-D)

The fundamental property of biological systems is a coherent state far from thermodynamic equilibrium excited and sustained by energy supply. Mitochondria in eukaryotic cells produce energy and form conditions for excitation of oscillations in microtubules. Microtubule polar oscillations generate a coherent state far from thermodynamic equilibrium which makes possible cooperation of cells in the tissue. Mitochondrial dysfunction (the Warburg effect) in cancer development breaks down energy of the coherent state far from thermodynamic equilibrium and excludes the afflicted cell from the ordered multicellular tissue system. Cancer lowering of energy and coherence of the state far from thermodynamic equilibrium is the biggest difference from the healthy cells. Cancer treatment should target mitochondrial dysfunction to restore the coherent state far from thermodynamic equilibrium, apoptotic pathway, and subordination of the cell in the tissue. A vast variety of genetic changes and other disturbances in different cancers can result in several triggers of mitochondrial dysfunction. In cancers with the Warburg effect, mitochondrial dysfunction can be treated by inhibition of four isoforms of pyruvate dehydrogenase kinases. Treatment of the reverse Warburg effect cancers would be more complicated. Disturbances of cellular electromagnetic activity by conducting and asbestos fibers present a special problem of treatment
Trvalý link: http://hdl.handle.net/11104/0240480