Electrodynamic activity of healthy and cancer cells

0436552 - ÚFE 2015 RIV GB eng C - Konferenční příspěvek (zahraniční konf.)
Pokorný, Jiří
Electrodynamic activity of healthy and cancer cells.
9TH INTERNATIONAL FROHLICH'S SYMPOSIUM: ELECTRODYNAMIC ACTIVITY OF LIVING CELLS (INCLUDING MICROTUBULE COHERENT MODES AND CANCER CELL PHYSICS). Vol. 329. Bristol: IOP, 2011 - (Cifra, M.; Pokorny, J.; Kučera, O.), 012007. ISSN 1742-6588.
[9th International Frohlich's Symposium on Electrodynamic Activity of Living Cells - Including Microtubule Coherent Modes and Cancer Cell Physics. Praha (CZ), 01.07.2011-03.07.2011]
Grant CEP: GA ČR(CZ) GAP102/11/0649
Výzkumný záměr: CEZ:AV0Z20670512
Klíčová slova: Boundary elements * Cancer cells * Electric dipole
Kód oboru RIV: JA - Elektronika a optoelektronika, elektrotechnika

Microtubules in the cell form a structure capable of generating electrodynamic field and mitochondria form their supporting system for physical processes including energy supply. Mitochondria transfer protons from their matrix space into cytosol, create strong static field around them that causes ordering of water and altering it into quasi-elastic medium with reduced viscous damping. Microtubules are composed of heterodimers that are electric dipoles. Microtubule oscillations generate an electrodynamic field. The greatest energy supply may be provided by liberation of non-utilized energy from mitochondria. Microtubules and mitochondria form a unique cooperating system in the cell. Mitochondria form a boundary element whose function depends on chemical-genetic control but their output is essential for physical processes in the cell. Mitochondrial dysfunction in cancer cells results in diminished intensity of the static electric field, disturbed water ordering, increased damping of microtubule oscillations and their shift towards linear region, and decreased energy supply. Power and coherence of oscillations and generated electrodynamic field is weakened. Malignant properties of cancer cell, in particular local invasion and metastasis, may depend on disturbed electrodynamic field. Nanotechnology is promising for investigation of electrodynamic activity in living cells
Trvalý link: http://hdl.handle.net/11104/0240261