Počet záznamů: 1
Tailor-Made Fluorescent Trilobolide To Study Its Biological Relevance
- 1.0436080 - ÚEM 2015 RIV US eng J - Článek v odborném periodiku
Jurášek, M. - Rimpelová, S. - Kmoníčková, Eva - Drašar, P. - Ruml, T.
Tailor-Made Fluorescent Trilobolide To Study Its Biological Relevance.
Journal of Medicinal Chemistry. Roč. 57, č. 19 (2014), s. 7947-7954. ISSN 0022-2623. E-ISSN 1520-4804
Grant ostatní: GA ČR(CZ) GA14-28334S; GA MŠMT(CZ) 20/2014
Program: GA
Institucionální podpora: RVO:68378041
Klíčová slova: trilobolide * nitric oxide * endoplasmic reticulum
Kód oboru RIV: FR - Farmakologie a lékárnická chemie
Impakt faktor: 5.447, rok: 2014
Anotace v a.j.: Trilobolide (Tb) is a potent natural counterpart of thapsigargin. The live-cell imaging of the prepared bioconjugates brought clear evidence that Tb–Bodipy localized in the endoplasmic reticulum (ER) of various cancer cell lines. Cytotoxicity of Tb conjugates and impact on the mitochondrial physiology and nitric oxide release and cytokine secretion were also studied.
Trvalý link: http://hdl.handle.net/11104/0239877
Počet záznamů: 1