Počet záznamů: 1
RADAMOL tool: Role of radiation quality and charge transfer in damage distribution along DNA oligomer
- 1.0435969 - ÚJF 2015 RIV DE eng J - Journal Article
Štěpán, Václav - Davídková, Marie
RADAMOL tool: Role of radiation quality and charge transfer in damage distribution along DNA oligomer.
European Physical Journal D. Roč. 68, č. 8 (2014), s. 240-247. ISSN 1434-6060. E-ISSN 1434-6079
R&D Projects: GA MŠMT LD12008; GA MŠMT MP1002 Nano-IBCT
Grant - others:GA MŠk(CZ) LM2010005
Institutional support: RVO:61389005
Keywords : radiation damage * ionizations * DNA
Subject RIV: BO - Biophysics
Impact factor: 1.228, year: 2014 ; AIS: 0.454, rok: 2014
DOI: https://doi.org/10.1140/epjd/e2014-50068-8
Theoretical modeling is a powerful tool to predict radiation damage of biomolecules such as DNA, proteins and more complex biological targets. In this paper, we present damage distributions along a DNA oligomer irradiated by 10 keV electrons, 1, 2, 5, 10 and 20 MeV protons and alpha particles predicted by the simulation tool RADAMOL. The scavengeable damage of base and deoxyribose moieties due to radical attack is more important in the studied system than unscavengeable ionizations of the DNA target and surrounding bound water layer. Radiation quality does not modify distribution of primary damages along the DNA, but changes overall damage yields. For the first time, electron and hole migration along the DNA macromolecule has been taken into account in the simulation procedure. The effect of these processes on distribution of DNA damages is demonstrated.
Permanent Link: http://hdl.handle.net/11104/0239814
Počet záznamů: 1