Backbone resonance assignments of the outer membrane lipoprotein FrpD from Neisseria meningitidis

0435351 - ÚOCHB 2015 RIV DE eng J - Článek v odborném periodiku
Bumba, Ladislav - Sviridova, E. - Kutá-Smatanová, Ivana - Řezáčová, Pavlína - Veverka, Václav
Backbone resonance assignments of the outer membrane lipoprotein FrpD from Neisseria meningitidis.
Biomolecular NMR Assignments. Roč. 8, č. 1 (2014), s. 53-55. ISSN 1874-2718. E-ISSN 1874-270X
Grant CEP: GA ČR(CZ) GAP207/11/0717; GA MŠMT(CZ) LK11205
Institucionální podpora: RVO:61388963 ; RVO:61388971 ; RVO:67179843
Klíčová slova: Neisseria meningitidis * FrpC * FrpD * backbone assignments * NMR * iron-regulated protein
Kód oboru RIV: CE - Biochemie
Impakt faktor: 0.760, rok: 2014

The iron-regulated FrpD protein is a unique lipoprotein embedded into the outer membrane of the Gram-negative bacterium Neisseria meningitidis. The biological function of FrpD remains unknown but might consist in anchoring to the bacterial cell surface the Type I-secreted FrpC protein, which belongs to a Repeat in ToXins (RTX) protein family and binds FrpD with very high affinity (K (d) = 0.2 nM). Here, we report the backbone H-1, C-13, and N-15 chemical shift assignments for the FrpD(43-271) protein that allow us to characterize the intimate interaction between FrpD and the N-terminal domain of FrpC.
Trvalý link: http://hdl.handle.net/11104/0239252