Auxarthron ostraviense sp nov., and A. umbrinum associated with non-dermatophytic onychomycosis

0435291 - MBÚ 2015 RIV GB eng J - Článek v odborném periodiku
Hubka, Vít - Dobiášová, S. - Lysková, P. - Mallátová, N. - Chlebková, J. - Skořepová, M. - Kubátová, A. - Dobiáš, R. - Chudíčková, Milada - Kolařík, Miroslav
Auxarthron ostraviense sp nov., and A. umbrinum associated with non-dermatophytic onychomycosis.
Medical Mycology. Roč. 51, č. 6 (2013), s. 614-624. ISSN 1369-3786. E-ISSN 1460-2709
Institucionální podpora: RVO:61388971
Klíčová slova: antifungal susceptibility testing * cycloheximide resistance * keratinophilic fungi
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 2.261, rok: 2013

Auxarthron is a genus within the Onygenales encompassing keratinophilic species with typical ascomata (gymnothecia) consisting of anastomosing network of thick-walled hyphae and small globose or oblate ascospores. No association of this genus with clinically relevant cases of human or animal infection has been reported. This paper describes the isolation of an undescribed Auxarthron species as an agent of proven onychomycosis affecting almost all fingernails in a man with psoriasis. The causality of the isolated fungus was verified by repeated sampling and direct microscopy revealing irregular septate hyphae. Based on micro-and macromorphological features and unique sequence data (ITS region, benA and RPB2 gene), the isolated fungus is proposed as the new species A. ostraviense. The sibling species of A. ostraviense, A. umbrinum, was isolated from three patients with suspected onychomycosis and a detailed clinical history is provided for one of these patients. All four isolates were tested for susceptibility to selected antifungal agents. Terbinafine and clotrimazole appear to be effective in vitro. The morphological identification of Auxarthron spp. is non-trivial, time-consuming and requires cultivation media other than Sabouraud glucose agar which is routinely used in dermatomycology.
Trvalý link: http://hdl.handle.net/11104/0239212