Determining Omics Spatiotemporal Dimensions Using Exciting New Nanoscopy Techniques to Assess Complex Cell Responses to DNA Damage: PART A-Radiomics

0435159 - BFÚ 2015 RIV US eng J - Článek v odborném periodiku
Falk, Martin - Hausmann, M. - Lukášová, Emilie - Biswas, A. - Hildenbrand, G. - Davídková, Marie - Krasavin, E. - Kleibl, Z. - Falková, Iva - Ježková, L. … celkem 19 autorů
Determining Omics Spatiotemporal Dimensions Using Exciting New Nanoscopy Techniques to Assess Complex Cell Responses to DNA Damage: PART A-Radiomics.
Critical Reviews in Eukaryotic Gene Expression. Roč. 24, č. 3 (2014), s. 205-223. ISSN 1045-4403. E-ISSN 2162-6502
Grant CEP: GA ČR(CZ) GBP302/12/G157; GA ČR(CZ) GAP302/10/1022; GA MŠMT(CZ) LD12039; GA MŠMT(CZ) LD12008; GA MŠMT(CZ) EE2.3.30.0030
Institucionální podpora: RVO:68081707 ; RVO:61389005
Klíčová slova: Omics * ionizing radiation * low-dose dilemma
Kód oboru RIV: BO - Biofyzika; JF - Jaderná energetika (UJF-V)
Impakt faktor: 1.571, rok: 2014

Recent ground-breaking developments in Omics have generated new hope for overcoming the complexity and variability of biological systems while simultaneously shedding more light on fundamental radiobiological questions that have remained unanswered for decades. In the era of Omics, our knowledge of how genes and proteins interact in the frame of complex networks to preserve genome integrity has been rapidly expanding. Nevertheless, these functional networks must be observed with strong correspondence to the cell nucleus, which is the main target of ionizing radiation. Nuclear architecture and nuclear processes, including DNA damage responses, are precisely organized in space and time. Information regarding these intricate processes cannot be achieved using high-throughput Omics approaches alone, but requires sophisticated structural probing and imaging.
Trvalý link: http://hdl.handle.net/11104/0239089