Distribution of glycine receptors on the surface of the mature calyx of Held nerve terminal

0434731 - ÚEM 2015 RIV CH eng J - Článek v odborném periodiku
Trojanová, Johana - Kulik, A. - Janáček, Jiří - Králíková, Michaela - Syka, Josef - Tureček, Rostislav
Distribution of glycine receptors on the surface of the mature calyx of Held nerve terminal.
Frontiers in Neural Circuits. Roč. 8, OCT 6 (2014), s. 120. E-ISSN 1662-5110
Grant CEP: GA ČR(CZ) GAP303/11/0131; GA ČR(CZ) GBP304/12/G069
Institucionální podpora: RVO:68378041 ; RVO:67985823
Klíčová slova: pre-embedding immunoelectron microscopy * presynaptic * glycine receptor
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 3.568, rok: 2014

We examined the distribution of glycine receptors (GlyRs) in the rat glutamatergic calyx of Held nerve terminal using high-resolution pre-embedding immunoelectron microscopy. Increased densities of GlyRs were found in calyceal swellings where the receptors preferentially occupied membrane regions presumably accessible by ambient glycine. The sites with increased GlyR concentrations were found in swellings tightly juxtaposed with GABA/glycinergic nerve endings. Our results support the concept of an indirect mechanism underlying the modulatory effects of calyceal GlyRs.
Trvalý link: http://hdl.handle.net/11104/0238728