In Vivo Initiation of Clock Gene Expression Rhythmicity in Fetal Rat Suprachiasmatic Nuclei

0434397 - FGÚ 2015 RIV US eng J - Článek v odborném periodiku
Houdek, Pavel - Sumová, Alena
In Vivo Initiation of Clock Gene Expression Rhythmicity in Fetal Rat Suprachiasmatic Nuclei.
PLoS ONE. Roč. 9, č. 9 (2014), e107360. ISSN 1932-6203. E-ISSN 1932-6203
Grant CEP: GA ČR(CZ) GAP303/12/1108
Institucionální podpora: RVO:67985823
Klíčová slova: circadian * suprachiasmatic nuclei * ontogenesis * clock gene * entrainment * rat
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 3.234, rok: 2014

Results of the study demonstrate that the circadian clock in the fetal rat suprachiasmatic nuclei develops gradually. At embryonic day 19 (E19), i.e., 4 days before delivery, the rhythms in expression of canonical clock genes Per2 and Bmal1 were absent and the clock developed just before birth. Expression of the clock gene Nr1d1 was rhythmic at E19 in absence of other clock gene expression rhythms and was thus likely driven by maternal cues instead of the core clockwork. The result suggest a molecular mechanism of how the rhythmic maternal cues entrain the developing fetal clock in the suprachiasmatic nuclei in vivo
Trvalý link: http://hdl.handle.net/11104/0238470