Down-regulation of adipogenesis of mesenchymal stem cells by oscillating high-gradient magnetic fields and mechanical vibration

0433524 - FZÚ 2015 RIV US eng J - Článek v odborném periodiku
Zablotskyy, Vitaliy A. - Lunov, Oleg - Novotná, Božena - Churpita, Olexandr - Trošan, Peter - Holáň, Vladimír - Syková, Eva - Dejneka, Alexandr - Kubinová, Šárka
Down-regulation of adipogenesis of mesenchymal stem cells by oscillating high-gradient magnetic fields and mechanical vibration.
Applied Physics Letters. Roč. 105, č. 10 (2014), "103702-1"-"103702-4". ISSN 0003-6951. E-ISSN 1077-3118
Grant CEP: GA ČR GAP304/11/0653; GA ČR(CZ) GAP304/12/1370; GA MŠMT LO1309
Grant ostatní: AV ČR(CZ) M100101219
Institucionální podpora: RVO:68378271 ; RVO:68378041
Klíčová slova: stem cells * cytoskeleton * magnetic field * cell growth
Kód oboru RIV: BO - Biofyzika; FH - Neurologie, neurochirurgie, neurovědy (UEM-P)
Impakt faktor: 3.302, rok: 2014

Here, we show that oscillating high-gradient magnetic field (HGMF) and mechanical vibration affect adipogenic differentiation of mesenchymal stem cells by the transmission of mechanical stress to the cell cytoskeleton, resulting in F-actin remodelling and subsequent down-regulation of adipogenic genes adiponectin, PPARγ, and AP2. Our findings propose an insight into the regulation of cellular nanomechanics, and provide a basis for better controlled down-regulation of stem cell adipogenesis by HGMF, which may facilitate the development of challenging therapeutic strategies suitable for the remote control of biological systems.
Trvalý link: http://hdl.handle.net/11104/0237730