Chemistry of silybin

0433202 - MBÚ 2015 RIV GB eng J - Článek v odborném periodiku
Biedermann, David - Vavříková, Eva - Cvak, L. - Křen, Vladimír
Chemistry of silybin.
Natural Product Reports. Roč. 31, č. 9 (2014), s. 1138-1157. ISSN 0265-0568. E-ISSN 1460-4752
Grant CEP: GA ČR(CZ) GAP301/11/0662; GA MŠMT LH13097; GA MŠMT(CZ) LD14096; GA MŠMT(CZ) LD13042
Institucionální podpora: RVO:61388971
Klíčová slova: silybin * Silybum marianum * separation
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 10.107, rok: 2014

Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a number of semisynthetic derivatives prepared in an effort to modulate and better target the biological activities of silybin or to improve its physical properties, such as its solubility. A fundamental breakthrough in silybin chemistry was the determination of the absolute configurations of silybin A and silybin B, and the development of methods for their separation. This review covers articles dealing with silybin chemistry and also summarizes all the derivatives prepared
Trvalý link: http://hdl.handle.net/11104/0237462