Isoquercitrin: Pharmacology, toxicology, and metabolism

0433017 - MBÚ 2015 RIV GB eng J - Článek v odborném periodiku
Valentová, Kateřina - Vrba, J. - Bancířová, M. - Ulrichová, J. - Křen, Vladimír
Isoquercitrin: Pharmacology, toxicology, and metabolism.
Food and Chemical Toxicology. Roč. 68, JUN 2014 (2014), s. 267-282. ISSN 0278-6915. E-ISSN 1873-6351
Grant CEP: GA ČR GPP301/12/P381; GA MŠMT(CZ) LD13041; GA MŠMT(CZ) 7E11011; GA ČR(CZ) GAP301/11/0767
Grant ostatní: GA ČR(CZ) GAP303/12/G163
Program: GA
Institucionální podpora: RVO:61388971
Klíčová slova: Quercetin-3-glucoside * Quercetin-3-O-beta-D-glucopyranoside * Enzymatically modified isoquercitrin
Kód oboru RIV: CE - Biochemie
Impakt faktor: 2.895, rok: 2014

The flavonoid isoquercitrin (quercetin-3-O-beta-D-glucopyranoside) is commonly found in medicinal herbs, fruits, vegetables and plant-derived foods and beverages. This article reviews the occurrence, preparation, bioavailability, pharmacokinetics, toxicology and biological activity of isoquercitrin and "enzymatically modified (alpha-glucosylated) isoquercitrin" (EMIQ). Pure isoquercitrin can now be obtained on a large scale by enzymatic rutin hydrolysis with alpha-L-rhamnosidase. Isoquercitrin has higher bioavailability than quercetin and displays a number of chemoprotective effects both in vitro and in vivo, against oxidative stress, cancer, cardiovascular disorders, diabetes and allergic reactions. Although small amounts of intact isoquercitrin can be found in plasma and tissues after oral application, it is extensively metabolized in the intestine and the liver
Trvalý link: http://hdl.handle.net/11104/0237299