Access to bifunctionalized biomolecular platforms using oxime ligation

0432688 - MBÚ 2015 RIV NL eng J - Článek v odborném periodiku
Křenek, Karel - Gažák, Radek - Daskhan, G. Ch. - Garcia, J. - Fiore, M. - Dumy, P. - Šulc, Miroslav - Křen, Vladimír - Renaudet, O.
Access to bifunctionalized biomolecular platforms using oxime ligation.
Carbohydrate Research. Roč. 393, JUL 2014 (2014), s. 9-14. ISSN 0008-6215. E-ISSN 1873-426X
Grant CEP: GA MŠMT(CZ) LD13042
Institucionální podpora: RVO:61388971
Klíčová slova: Chemoselective ligation * Glycocluster * Cyclopeptide
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 1.929, rok: 2014

This paper describes an efficient oxime ligation strategy to prepare multivalent conjugates wherein peptides alone or in combination with carbohydrate or oxime groups were coupled to a cyclopeptide scaffold. To demonstrate the versatility of this approach, two classes of conjugates have been prepared. In one class, we attached two or four peptide sequences to the cyclopeptide core together with free oxime groups, while the second class contains an additional substitution with four or two monosaccharides. The well-defined structure of these conjugates was confirmed by high-resolution mass spectrometry
Trvalý link: http://hdl.handle.net/11104/0237066