Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants

0432596 - ÚEM 2015 RIV IE eng J - Článek v odborném periodiku
Líbalová, Helena - Krčková, S. - Uhlířová, Kateřina - Milcová, Alena - Schmuczerová, Jana - Cigánek, M. - Kléma, J. - Machala, M. - Šrám, Radim - Topinka, Jan
Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants.
Toxicology Letters. Roč. 225, č. 3 (2014), s. 350-357. ISSN 0378-4274. E-ISSN 1879-3169
Grant CEP: GA ČR GAP503/11/0142
Institucionální podpora: RVO:68378041
Klíčová slova: air pollutin * DNA adducts * complex mixtures
Kód oboru RIV: DN - Vliv životního prostředí na zdraví
Impakt faktor: 3.262, rok: 2014

We compared the genotoxicity and aryl hydrocarbon receptor (AhR)-dependent transcriptional changes of selected target genes in human lung epithelial A549 cells incubated for 24 h, either with extractable organic matter (EOMs) from airborne particles <2.5 μm (PM2.5) Our results suggested inhibition of formation of B[a]P-induced DNA adducts compared to individual B[a]P, probably attributable to competitive inhibition by other non-genotoxic EOM components.
Trvalý link: http://hdl.handle.net/11104/0236980