Histological aspects of the small intestine under variable feed restriction: The effects of short and intense restriction on a growing rabbit model

0432593 - ÚEM 2015 RIV GR eng J - Článek v odborném periodiku
Makovický, P. - Tůmová, E. - Volek, Z. - Makovický, P. - Vodička, Pavel
Histological aspects of the small intestine under variable feed restriction: The effects of short and intense restriction on a growing rabbit model.
Experimental and Therapeutic Medicine. Roč. 8, č. 5 (2014), s. 1623-1627. ISSN 1792-0981. E-ISSN 1792-1015
Grant CEP: GA MZd(CZ) NT13424
Institucionální podpora: RVO:68378041
Klíčová slova: histopathology * nutrition * rabbit
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 1.269, rok: 2014

We investigated the effect of seven days of feed restriction (between days 42 and 49) on the morphology of the small intestine in experimental rabbit models. The first control group (n=20) received feed ad libitum (ADL group), the second (R1) experimental group (n=20) was fed 50 g feed per rabbit per day and the third (R2) experimental group (n=20) received 65 g feed per rabbit per day. Duodenal samples were collected when the rabbits were aged 49, 56, 63 and 70 days. The mean villus height, crypt depth and small intestine length were measured. Significant interactions (P<0.001) between group and age were identified in the villi height and crypt depths. The maximum mean villus height was found in the R2 group in 56 days old rabbits, while the minimum was found in the ADL group in 49 days old rabbits. The longest (P<0.001) small intestine was measured in the R1 group in 63 days old rabbits, while the shortest was in the ADL group in 49 days old rabbits. The models show that villus height, crypt depth and the length of the small intestine change with the intensity of feed restriction and age.
Trvalý link: http://hdl.handle.net/11104/0236956