Xenobiotic administration affects biotransformations of thyroid hormones in the rat

0432139 - FGÚ 2015 RIV SK eng C - Konferenční příspěvek (zahraniční konf.)
Pavelka, Stanislav - Soukup, Tomáš - Tribulová, N.
Xenobiotic administration affects biotransformations of thyroid hormones in the rat.
Zborník príspevkov z medzinárodného vedeckého sympózia“Priemyslná toxikológia 2014“. Bratislava: Slovenská technická univerzita, 2014, s. 109-115. ISBN 978-80-227-4181-1.
[Priemyselná toxikológia 2014. Svit, Vysoké Tatry (SK), 18.06.2014-20.06.2014]
Grant CEP: GA MŠMT(CZ) 7AMB14SK123
Institucionální podpora: RVO:67985823
Klíčová slova: enzyme * thyroid hormone * xenobiotic
Kód oboru RIV: ED - Fyziologie

With the use of our newly developed radiometric enzyme assays for the determination of enzyme activities of iodothyronine deiodinases (IDs) of the types D1, D2 and D3, and adapted radiometric assays for quantification of iodothyronine sulfotransferases (ST) and uridine 5‘-diphospho glucuronyltransferase (UDP-GT), we proved thyrotoxic effects of excessive exogenous bromide and perchlorate ions. Profound changes in enzyme activities were also determined in rats treated with an antidepressant drug fluoxetine (Fluox), especially in case of IDs in their pituitary and cerebellum
Trvalý link: http://hdl.handle.net/11104/0236608