Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

0431859 - ÚEM 2015 RIV US eng J - Článek v odborném periodiku
Wolpin, B. M. - Rizzato, C. - Kraft, P. - Kooperberg, Ch. - Petersen, G. M. - Wang, Z. - Arslan, A. A. - Beane-Freeman, L. - Bracci, P. M. - Buring, J. - Canzian, F. - Duell, E. J. - Gallinger, S. - Giles, G.G. - Goodman, G. E. - Goodman, P. J. - Jacobs, E. J. - Kamineni, A. - Klein, A. P. - Kolonel, L. N. - Kulke, M. H. - Li, D. - Malats, N. - Olson, S. H. - Risch, H. A. - Sesso, H. D. - Visvanathan, K. - White, E. - Zheng, W. - Abnet, Ch. C. - Albanes, D. - Andreotti, G. - Austin, M. A. - Barfield, R. - Basso, D. - Berndt, S. I. - Boutron-Ruault, M. Ch. - Brotzman, M. - Büchler, M. W. - Bueno-de-Mesquita, H. B. - Bugert, P. - Burdette, L. - Campa, D. - Caporaso, N. E. - Capurso, G. - Chung, Ch. - Cotterchio, M. - Costello, E. - Elena, J. - Funel, N. - Gaziano, J. M. - Giese, N. A. - Giovannucci, E. L. - Goggins, M. - Gorman, M. J. - Gross, M. - Haiman, Ch. A. - Hassan, M. - Helzlsouer, K. J. - Henderson, B. E. - Holly, E. A. - Hu, N. - Hunter, D. J. - Innocenti, F. - Jenab, M. - Kaaks, R. - Key, T. J. - Khaw, K. T. - Klein, E. A. - Kogevinas, M. - Krogh, V. - Kupcinskas, J. - Kurtz, R. C. - LaCroix, A. - Landi, M. T. - Landi, S. - Le Marchand, L. - Mambrini, A. - Mannisto, S. - Milne, R. L. - Nakamura, Y. - Oberg, A. L. - Owzar, K. - Patel, A. V. - Peeters, P. H. M. - Peters, U. - Pezzilli, R. - Piepoli, A. - Porta, M. - Real, F. X. - Riboli, E. - Rothman, N. - Scarpa, A. - Shu, X. O. - Silverman, D. T. - Souček, P. - Sund, M. - Talar-Wojnarowska, R. - Taylor, P. R. - Theodoropoulos, G. E. - Thornquist, M. - Tjonneland, A. - Tobias, G. S. - Trichopoulos, D. - Vodička, Pavel - Wactawski-Wende, J. - Wentzensen, N. - Wu, Ch. - Yu, H. - Yu, K. - Zeleniuch-Jacquotte, A. - Hoover, R. - Hartge, P. - Fuchs, Ch. - Chanock, S. J. - Stolzenberg-Solomon, R. S. - Amundadottir, L. T.
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
Nature Genetics. Roč. 46, č. 9 (2014), s. 994-1000. ISSN 1061-4036. E-ISSN 1546-1718
Institucionální podpora: RVO:68378041
Klíčová slova: disease * variants * genetic susceptibility
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 29.352, rok: 2014

We performed a multistage genome-wide association study including 7683 individuals with pancreatic cancer and 14397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74–0.84, P = 3.0 × 10−12), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30–1.65, P = 1.1 × 10−10), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10–1.20, P = 2.4 × 10−9) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12–1.25, P = 1.2 × 10−8). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76–0.85, P = 9.8 × 10−14). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10−7) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.
Trvalý link: http://hdl.handle.net/11104/0236489