Pyrrolidine nucleotide analogs with a tunable conformation

0431792 - ÚOCHB 2015 RIV DE eng J - Článek v odborném periodiku
Poštová Slavětínská, Lenka - Rejman, Dominik - Pohl, Radek
Pyrrolidine nucleotide analogs with a tunable conformation.
Beilstein Journal of Organic Chemistry. Roč. 10, Aug 22 (2014), s. 1967-1980. ISSN 1860-5397. E-ISSN 1860-5397
Grant CEP: GA ČR GA13-24880S
Institucionální podpora: RVO:61388963
Klíčová slova: conformation * NMR * nucleic acids * nucleotide analog * phosphonic acid * pseudorotation * pyrrolidine
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 2.757, rok: 2014
http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-10-205

Conformational preferences of the pyrrolidine ring in nucleotide analogs 7-14 were investigated by means of NMR and molecular modeling. The effect of the relative configuration of hydroxy and nucleobase substituents as well as the effect of the alkylation or acylation of the pyrrolidine nitrogen atom on the conformation of the pyrrolidine ring were studied. The results of a conformational analysis show that the alkylation/acylation can be effectively used for tuning the pyrrolidine conformation over the whole pseudorotation cycle.
Trvalý link: http://hdl.handle.net/11104/0236420