Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate

0431289 - FGÚ 2015 RIV GB eng J - Článek v odborném periodiku
Rauchová, Hana - Vokurková, Martina - Drahota, Zdeněk
Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate.
International Journal of Biochemistry and Cell Biology. Roč. 53, AUG (2014), s. 409-413. ISSN 1357-2725. E-ISSN 1878-5875
Grant CEP: GA ČR(CZ) GAP304/12/0259
Institucionální podpora: RVO:67985823
Klíčová slova: brown adipose tissue mitochondria * oxygen consumption * glycerol-3-phosphate * succinate * reactive oxygen species
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 4.046, rok: 2014

Tocopheryl succinate (TOS), a redox-silent analogue of vitamin E, suppresses cell growth in a number of clinical and experimental cancers, inhibits mitochondrial dehydrogenase (SDH) and activates reactive oxygen species (ROS) generation. The aim of this study was to test whether TOS also inhibits glycerol-3-phosphate dehydrogenase (mGPDH), another flavoprotein-dependent enzyme of the mitochondrial respiratory chain because there are differences between electron transfer pathway from SDH and mGPDH to coenzyme Q pool. We found that TOS-induced inhibition of mGPDH is more pronounced than TOS-induced inhibition of SDH and that the inhibitory effect of TOS for both substrates is exerted at different location of the particular dehydrogenase. Our data indicate that the inhibition of mGPDH activity could also play a role in TOS-induced growth suppression in neoplastic cells
Trvalý link: http://hdl.handle.net/11104/0235875