Involvement of BKCa and KV potassium channels in cAMP-induced vasodilation: their insufficient function in genetic hypertension

0431288 - FGÚ 2015 RIV CZ eng J - Článek v odborném periodiku
Pintérová, Mária - Behuliak, Michal - Kuneš, Jaroslav - Zicha, Josef
Involvement of BKCa and KV potassium channels in cAMP-induced vasodilation: their insufficient function in genetic hypertension.
Physiological Research. Roč. 63, č. 3 (2014), s. 275-285. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR(CZ) GA305/09/0336; GA ČR(CZ) GAP304/12/0259; GA MŠMT(CZ) 1M0510
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: isoprenaline * cAMP * potassium channels * calcium channels
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 1.293, rok: 2014

The objective of our in vivo study was to evaluate whether the impaired function of BKCa and/or KV channels is responsible for abnormal cAMP-induced vasodilatation in genetic hypertension. Under basal conditions, the vasodilator action of both K(+) channels was enhanced in SHR compared to WKY rats. However, the overall contribution of K(+) channels to cAMP-induced vasodilator mechanisms is insufficient in genetic hypertension since a concurrent activation of both K(+) channels by cAMP overproduction is necessary for the prevention of BP rise elicited by acute NO/cGMP deficiency in SHR. This might be caused by less effective activation of these K(+) channels by cAMP in SHR. In conclusion, K(+) channels seem to have higher activity in SHR, but their vasodilator action cannot match sufficiently the augmented vasoconstriction in this hypertensive strain
Trvalý link: http://hdl.handle.net/11104/0235874