0431253 - ÚEM 2015 RIV US eng J - Článek v odborném periodiku
Honsa, Pavel - Pivoňková, Helena - Harantová, Lenka - Butenko, Olena - Kriška, Ján - Džamba, Dávid - Rusňáková, Vendula - Valihrach, Lukáš - Kubista, Mikael - Anděrová, Miroslava
Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.
Glia. Roč. 62, č. 12 (2014), s. 2004-2021. ISSN 0894-1491. E-ISSN 1098-1136
Grant CEP: GA ČR GA13-02154S; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) ED1.1.00/02.0109
Grant ostatní: GA MŠk(CZ) CZ.1.07/2.3.00/30.0045
Institucionální podpora: RVO:68378041 ; RVO:86652036
Klíčová slova: Astrocytes * focal and global cerebral ischemia * HCN channels
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 6.031, rok: 2014

The increased expression of HCN channels in reactive astrocytes was detected on mRNA and protein levels following ischemic injury and the presence of functional HCN channels and their modulation by cAMP and ZD7288 was revealed by patch-clamp technique. Our results demonstrate that regardless of the type of ischemic injury, reactive astrocytes express HCN channels, which could therefore be an important therapeutic target in post-stroke therapy.
Trvalý link: http://hdl.handle.net/11104/0239346