Počet záznamů: 1
Synthesis of poly[N-(2-hydroxypropyl)methacrylamide] conjugates of inhibitors of the ABC transporter that overcome multidrug resistance in doxorubicin-resistant P388 cells in vitro
- 1.0431003 - ÚMCH 2015 RIV US eng J - Článek v odborném periodiku
Šubr, Vladimír - Sivák, Ladislav - Koziolová, Eva - Braunová, Alena - Pechar, Michal - Strohalm, Jiří - Kabešová, Martina - Říhová, Blanka - Ulbrich, Karel - Kovář, Marek
Synthesis of poly[N-(2-hydroxypropyl)methacrylamide] conjugates of inhibitors of the ABC transporter that overcome multidrug resistance in doxorubicin-resistant P388 cells in vitro.
Biomacromolecules. Roč. 15, č. 8 (2014), s. 3030-3043. ISSN 1525-7797. E-ISSN 1526-4602
Grant CEP: GA ČR GAP301/12/1254; GA MŠMT(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:61389013 ; RVO:61388971
Klíčová slova: N-(2-hydroxypropyl)methacrylamide copolymers * multidrug resistance * P-glycoprotein inhibitors
Kód oboru RIV: CD - Makromolekulární chemie; FD - Onkologie a hematologie (MBU-M)
Impakt faktor: 5.750, rok: 2014
The effects of novel polymeric therapeutics based on water-soluble N-(2-hydroxypropyl)methacrylamide copolymers (P(HPMA)) bearing the anticancer drug doxorubicin (Dox), an inhibitor of ABC transporters, or both, on the viability and the proliferation of the murine monocytic leukemia cell line P388 (parental cell line) and its doxorubicin-resistant subline P388/MDR were studied in vitro.
Trvalý link: http://hdl.handle.net/11104/0236142
Počet záznamů: 1