Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients

0430218 - ÚEM 2015 RIV GB eng J - Článek v odborném periodiku
Vymetálková, Veronika - Slyšková, Jana - Korenková, Vlasta - Bielik, Ludovít - Langerová, Lucie - Procházka, Pavel - Rejhová, Alexandra - Schwarzová, L. - Pardini, B. - Naccarati, Alessio - Vodička, Pavel
Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients.
BMC Medical Genetics. Roč. 15, č. 1 (2014), s. 17. E-ISSN 1471-2350
Grant CEP: GA AV ČR IAA500200917; GA ČR(CZ) GPP304/11/P715
Grant ostatní: GA MŠk(CZ) Prvouk-P27/LF1/1
Institucionální podpora: RVO:68378041 ; RVO:86652036
Klíčová slova: colorectal cancer * mismatch repair genes * expression levels
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 2.083, rok: 2014

The present study aimed at characterizing of epigenetic and gene expression profiles of MMR genes in sporadic CRC patients from the Czech Republic, a country with one of the highest incidences of this cancer all over Europe. In our study, we have observed different pattern of MMR genes expression according to tumor localization. However, a lack of association between methylation in MMR genes and their corresponding expressions was noticed in this study, the relationship between these two aspects is worthy to be analyzed in larger population studies and in pre-malignant stages.
Trvalý link: http://hdl.handle.net/11104/0235127