Novel properties of antimicrobial peptide anoplin

0429974 - ÚEB 2015 RIV US eng J - Článek v odborném periodiku
Jindřichová, Barbora - Burketová, Lenka - Novotná, Z.
Novel properties of antimicrobial peptide anoplin.
Biochemical and Biophysical Research Communications. Roč. 444, č. 4 (2014), s. 520-524. ISSN 0006-291X. E-ISSN 1090-2104
Grant CEP: GA ČR GA522/09/1693
Institucionální podpora: RVO:61389030
Klíčová slova: Anoplin * Antimicrobial peptide * Antifungal
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 2.297, rok: 2014

Antimicrobial decapeptide anoplin was tested for its antifungal activity against plant pathogen Leptosphaeria maculans and protection of Brassica napus plants from disease. To reveal the mode of action of the peptide, a natural form of anoplin amidated on C-terminus (ANP-NH2), and its carboxylated analog (ANP-OH) were used in the study. We demonstrated strong antifungal activity of anoplin in vitro regardless C-terminus modification. In addition we show that both ANP-NH2 and ANP-OH induce expression of defence genes in B. napus and protects plants from L. maculans infection. The results indicate that the amidation of anoplin is not essential for its antifungal and plant defence stimulating activities.
Trvalý link: http://hdl.handle.net/11104/0234921