Intermittent hemodialysis is superior to continuous veno-venous hemodialysis/hemodiafiltration to eliminate methanol and formate during treatment for methanol poisoning

0429828 - ÚFCH JH 2015 RIV US eng J - Článek v odborném periodiku
Zakharov, S. - Pelclová, D. - Navrátil, Tomáš - Běláček, J. - Kurcová, I. - Komzák, O. - Šálek, T. - Latta, J. - Turek, R. - Boček, R. - Kučera, C. - Hubáček, J. A. - Fenclová, Z. - Petřík, V. - Čermák, M. - Hovda, K. E.
Intermittent hemodialysis is superior to continuous veno-venous hemodialysis/hemodiafiltration to eliminate methanol and formate during treatment for methanol poisoning.
Kidney International. Roč. 86, č. 1 (2014), s. 199-207. ISSN 0085-2538. E-ISSN 1523-1755
Institucionální podpora: RVO:61388955
Klíčová slova: Intermittent hemodialysis * hemodiafiltration * methanol poisonings
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
Impakt faktor: 8.563, rok: 2014

During an outbreak of methanol poisonings in the Czech Republic in 2012, we were able to study methanol and formate elimination half-lives during intermittent hemodialysis (IHD) and continuous veno-venous hemodialysis/hemodiafiltration (CVVHD/HDF) and the relative impact of dialysate and blood flow rates on elimination. Data were obtained from 11 IHD and 13 CVVHD/HDF patients. Serum methanol and formate concentrations were measured by gas chromatography and an enzymatic method. The groups were relatively comparable, but the CVVHD/HDF group was significantly more acidotic (mean pH 6.9 vs. 7.1 IHD). The mean elimination half-life of methanol was 3.7 and formate 1.6 h with IHD, versus 8.1 and 3.6 h, respectively, with CVVHD/HDF (both significant). The 54% greater reduction in methanol and 56% reduction in formate elimination half-life during IHD resulted from the higher blood and dialysate flow rates. Increased blood and dialysate flow on the CVVHD/HDF also increased elimination significantly. Thus, IHD is superior to CVVHD/HDF for more rapid methanol and formate elimination, and if CVVHD/HDF is the only treatment available then elimination is greater with greater blood and dialysate flow rates.
Trvalý link: http://hdl.handle.net/11104/0234852