Activation of human RNase L by 5’-C-phosphonate-modified oligoadenylates

0429040 - ÚOCHB 2015 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Petrová, Magdalena - Buděšínský, Miloš - Zborníková, Eva - Panova, Natalya - Novák, Pavel - Rosenberg, Ivan
Activation of human RNase L by 5’-C-phosphonate-modified oligoadenylates.
Chemistry of Nucleic Acid Components. 16th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2014 - (Hocek, M.), s. 348-349. Collection Symposium Series, 14. ISBN 978-80-86241-50-0.
[Symposium on Chemistry of Nucleic Acid Components /16./. Český Krumlov (CZ), 08.06.2014-13.06.2014]
Grant CEP: GA ČR GA13-26526S; GA ČR GA13-24880S; GA TA ČR TA03010598
Institucionální podpora: RVO:61388963
Klíčová slova: human RNase L * oligoadenylates
Kód oboru RIV: CC - Organická chemie

Adeno’sine 5’-(S)-C-phosphonate (pCOHX) was prepared as monomer suitable for oligonucleotide synthesis. Modified tetramers pCOHXAAA and pCOHXAApCOHX were assembled on solid phase and evaluated for their ability to activate human RNase L.
Trvalý link: http://hdl.handle.net/11104/0234442