Počet záznamů: 1
5-(Pyren-1-yl)uracil UNA monomers: Synthesis, hybridization studies and i-motif stability
- 1.0429038 - ÚOCHB 2015 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Perlíková, Pavla - Pedersen, E. B. - Wengel, J.
5-(Pyren-1-yl)uracil UNA monomers: Synthesis, hybridization studies and i-motif stability.
Chemistry of Nucleic Acid Components. 16th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2014 - (Hocek, M.), s. 346-347. Collection Symposium Series, 14. ISBN 978-80-86241-50-0.
[Symposium on Chemistry of Nucleic Acid Components /16./. Český Krumlov (CZ), 08.06.2014-13.06.2014]
Grant ostatní: European Research Council(XE) FP7-268776
Institucionální podpora: RVO:61388963
Klíčová slova: 5-(pyren-1-yl)uracil UNA monomers * DNA * unlocked nucleic acids
Kód oboru RIV: CC - Organická chemie
We have used direct conjugation of a pyrene moiety to a uracil base in synthesis of novel pyrene-modified UNA building blocks. Oligonucleotides with bulge-incorporated pyrene-modified UNA monomers showed increased duplex thermal stability, whereas destabilizing effect was observed in fully matched duplexes and in i-motifs.
Trvalý link: http://hdl.handle.net/11104/0234441
Počet záznamů: 1