Natural variation of histone modification and its impact on gene expression in the rat genome

0429012 - FGÚ 2015 RIV US eng J - Článek v odborném periodiku
Rintisch, C. - Heinig, M. - Bauerfeind, A. - Schafer, S. - Mieth, Ch. - Patone, G. - Hummel, O. - Chen, W. - Cook, S. - Cuppen, E. - Colomé-Tatché, M. - Johannes, F. - Jansen, R. C. - Neil, H. - Werner, M. - Pravenec, Michal - Vingron, M. - Hubner, N.
Natural variation of histone modification and its impact on gene expression in the rat genome.
Genome Research. Roč. 24, JUN (2014), s. 942-953. ISSN 1088-9051. E-ISSN 1549-5469
Grant CEP: GA MŠMT(CZ) 7E10067; GA ČR(CZ) GAP301/10/0290; GA MŠMT(CZ) LL1204
Institucionální podpora: RVO:67985823
Klíčová slova: ChIP-seq * histone modification * gene expression * genetic linkage analysis
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 14.630, rok: 2014

Histone modifications are epigenetic marks that play fundamental roles in many biological processes including the control of chromatin-mediated regulation of gene expression. The integrated analysis of DNA variation together with histone methylation and gene expression levels showed that histone QTLs are an important predictor of gene expression and that a joint analysis significantly enhanced the prediction of gene expression traits (eQTLs). Our data suggest that genetic variation has widespread impact on histone trimethylation marks that may help to uncover novel genotype-phenotype relationships
Trvalý link: http://hdl.handle.net/11104/0234214