A virtual reality task based on animal research – spatial learning and memory in patients after the first episode of schizophrenia

0428984 - FGÚ 2015 RIV CH eng J - Článek v odborném periodiku
Fajnerová, Iveta - Rodriguez, M. - Levčík, David - Konrádová, L. - Mikoláš, P. - Brom, C. - Stuchlík, Aleš - Vlček, Kamil - Horáček, J.
A virtual reality task based on animal research – spatial learning and memory in patients after the first episode of schizophrenia.
Frontiers in Behavioral Neuroscience. Roč. 8, May 27 (2014), s. 157. ISSN 1662-5153
Grant CEP: GA MZd(CZ) NT13386
Grant ostatní: GA MZd(CZ) NT14291; GA MZd(CZ) NT13843
Institucionální podpora: RVO:67985823
Klíčová slova: schizophrenia * spatial navigation * learning and memory * virtual reality environment * cognitive deficit * Morris Water Maze (MWM) * psychotic disorders * spatial behavior
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 3.270, rok: 2014

In order to assess spatial abilities in schizophrenia and compare our results with the data obtained in animal models, we designed a virtual analog of the Morris water maze (MWM), the virtual Four Goals Navigation (vFGN) task. Twenty-nine patients after the first psychotic episode with schizophrenia symptoms and a matched group of healthy volunteers performed the vFGN task. They were required to find and remember four hidden goal positions in an enclosed virtual arena. Results from the vFGN task show impaired spatial learning ane memory in schizophrenia patients compared to the healthy controls in pointing, navigation accuracy and goal quadrant preference (in probe trials). Our results correspond well with the previous studies in animal models of schizophrenia and support the decline of spatial cognition in schizophrenia, indicating the usefulness of the vFGN task in future comparative research
Trvalý link: http://hdl.handle.net/11104/0234197