Počet záznamů: 1
Insights into the mechanism of action of bactericidal lipophosphonoxins
- 1.0428833 - ÚOCHB 2015 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Panova, Natalya - Zborníková, Eva - Šimák, Ondřej - Krásný, Libor - Kolář, M. - Látal, T. - Seydlová, G. - Rejman, Dominik
Insights into the mechanism of action of bactericidal lipophosphonoxins.
Chemistry of Nucleic Acid Components. 16th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2014 - (Hocek, M.), s. 115-118. Collection Symposium Series, 14. ISBN 978-80-86241-50-0.
[Symposium on Chemistry of Nucleic Acid Components /16./. Český Krumlov (CZ), 08.06.2014-13.06.2014]
Grant CEP: GA TA ČR TA02010035
Grant ostatní: GA ČR(CZ) GP13-18051P
Institucionální podpora: RVO:61388963 ; RVO:61388971
Klíčová slova: lipophosphonoxins * cytotoxicity * antibiotics
Kód oboru RIV: CC - Organická chemie
The advantages offered by antibiotics in the treatment of infectious diseases are endangered due to the increase in the number of antibiotic-resistant bacterial strains. This reduces the efficiency of antibiotic treatments and poses a serious health and economical problem. Currently, the need for novel antibiotics is becoming increasingly apparent. Recently, we discovered a series of compounds termed lipophosphonoxins exhibiting selective cytotoxicity towards gram-positive bacterial cells. The attempt to elucidate the mode of action of lipophosphonoxins is presented here.
Trvalý link: http://hdl.handle.net/11104/0234279
Počet záznamů: 1