Kinetics of neurotransmitter release in neuromuscular synapses of newborn and adult rats

0428434 - FGÚ 2015 RIV GB eng J - Článek v odborném periodiku
Khuzakhmetova, V. - Samigullin, D. - Nurullin, L. - Vyskočil, František - Nikolsky, E. - Bukharaeva, E.
Kinetics of neurotransmitter release in neuromuscular synapses of newborn and adult rats.
International Journal of Developmental Neuroscience. Roč. 34, MAY (2014), s. 9-18. ISSN 0736-5748. E-ISSN 1873-474X
Grant CEP: GA AV ČR(CZ) IAA500110905
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: ryanodine receptor * synaptic latency
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 2.580, rok: 2014

The kinetics of the phasic synchronous and delayed asynchronous release of acetylcholine quanta wasstudied at the neuromuscular junctions of aging rats from infant to mature animals at various frequen-cies of rhythmic stimulation of the motor nerve. We found that in infants 6 (P6) and 10 (P10) daysafter birth a strongly asynchronous phase of quantal release was observed, along with a reduced num-ber of quanta compared to the synapses of adults. Therefore, high degree of asynchrony of quantal release in infants is not associatedwith the activity of ryanodine receptors and with the liberation of calcium ions from intracellular calcium stores
Trvalý link: http://hdl.handle.net/11104/0233792