TRPV1 receptor inhibition decreases CCL2-induced hyperalgesia

0428171 - FGÚ 2015 RIV NL eng J - Článek v odborném periodiku
Špicarová, Diana - Adámek, Pavel - Kalynovska, Nataliia - Mrózková, Petra - Paleček, Jiří
TRPV1 receptor inhibition decreases CCL2-induced hyperalgesia.
Neuropharmacology. Roč. 81, JUN (2014), s. 75-84. ISSN 0028-3908. E-ISSN 1873-7064
Grant CEP: GA ČR(CZ) GA305/09/1228; GA ČR(CZ) GPP303/12/P510; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) LH12058
Grant ostatní: Univerzita Karlova(CZ) 253154
Institucionální podpora: RVO:67985823
Klíčová slova: pain * spinal cord * synaptic transmission * CCL2 * TRPV1 * EPSC
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 5.106, rok: 2014

Modulation of nociceptive synaptic transmission in the spinal cord is implicated in the development and maintenance of several pathological pain states. The chemokine CCL2 (CeC motif ligand 2) was shown to be an important factor in the development of neuropathic pain after peripheral nerve injury. In our experiments we have studied the effect of CCL2 application and TRPV1 (transient receptor potential vanilloid 1) receptor activation on nociceptive signaling and the modulation of synaptic transmission. Our results demonstrate that the activation of spinal TRPV1 receptors plays an important role in the modulation of nociceptive signaling induced by CCL2 application. The mechanisms of cooperation between the CCL2 activated receptors and TRPV1 receptors on the central branches of primary afferent fibers may be especially important during different pathological pain states and need to be further investigated
Trvalý link: http://hdl.handle.net/11104/0233575