Quantification of structural changes of UHMWPE components in total joint replacements

0427703 - ÚMCH 2015 RIV GB eng J - Článek v odborném periodiku
Fulín, P. - Pokorný, D. - Šlouf, Miroslav - Nevoralová, Martina - Vacková, Taťana - Dybal, Jiří - Pilař, Jan
Quantification of structural changes of UHMWPE components in total joint replacements.
BMC Musculoskeletal Disorders. Roč. 15, 28 March (2014), 109_1-109_8. E-ISSN 1471-2474
Grant CEP: GA TA ČR TA01011406; GA MZd NT12229
Institucionální podpora: RVO:61389013
Klíčová slova: UHMWPE * oxidative damage * residual radicals
Kód oboru RIV: FI - Traumatologie, ortopedie
Impakt faktor: 1.717, rok: 2014

At present time the number of implantations of joint replacements as well as their revisions increases. Higher demands are required on the quality and longevity of implants. The aim of this work was to determine the degree of oxidative degradation and the amount of free/residual radicals in selected ultra-high molecular weight polyethylene (UHMWPE) components of the joint replacements and demonstrate that the measured values are closely connected with quality and lifetime of the polymer components. We tested both new (4 samples) and explanted (4 samples) UHMWPE polymers for total joint replacements. The samples were characterized by infrared spectroscopy (IR), electron spin resonance (ESR) and microhardness (MH) test. The IR measurements yielded the values of oxidation index and trans-vinylene index. The ESR measurements gave the free radicals concentration. In the group of new polyethylene components, we found oxidation index values ranging from 0.00-0.03 to 0.24. The trans-vinylene index values ranged from 0.044 to 0.080. The value of free radical concentration was zero in virgin and also in sample of Beznoska Company and non-zero in the other samples. In the group of explanted components, the measured values were associated with their history, micromechanical properties and performance in vivo. We demonstrated that measuring of oxidative damage may help the orthopaedic surgeon in estimating the quality of UHMWPE replacement component and thus radically to avoid early joint replacement failure due to worse polyethylene quality.
Trvalý link: http://hdl.handle.net/11104/0233914