Recent progress in the genetics of spontaneously hypertensive rats

0427697 - FGÚ 2015 RIV CZ eng J - Článek v odborném periodiku
Pravenec, Michal - Křen, Vladimír - Landa, Vladimír - Mlejnek, Petr - Musilová, Alena - Šilhavý, Jan - Šimáková, Miroslava - Zídek, Václav
Recent progress in the genetics of spontaneously hypertensive rats.
Physiological Research. Roč. 63, Suppl.1 (2014), S1-S8. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA MŠMT(CZ) LL1204; GA MŠMT(CZ) LH12061; GA ČR(CZ) GAP303/10/0505; GA ČR(CZ) GAP301/10/0290; GA ČR(CZ) GAP301/12/0696; GA TA ČR(CZ) TA02010013; GA MŠMT(CZ) LH11049; GA ČR(CZ) GA13-04420S; GA MZd(CZ) NT14325
Institucionální podpora: RVO:67985823
Klíčová slova: spontaneously hypertensive rats * genetics * hypertension * left ventricular hypertrophy
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 1.293, rok: 2014

The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and accompanying metabolic disturbances. Recent advances in sequencing of genomes of BN-Lx and SHR progenitors of the BXH/HXB recombinant inbred (RI) strains as well as accumulation of multiple data sets of intermediary phenotypes in the RI strains, as well as in manipulation of the rat genome will enable identification genetic determinants at the molecular level
Trvalý link: http://hdl.handle.net/11104/0233194