A Comprehensive Web-based Platform For Domain-Specific Biological Models

0426649 - ÚVGZ 2014 RIV NL eng J - Článek v odborném periodiku
Klement, M. - Šafránek, D. - Děd, J. - Pejznoch, A. - Nedbal, Ladislav - Steuer, Ralf - Červený, Jan - Müller, Stefan
A Comprehensive Web-based Platform For Domain-Specific Biological Models.
Electronic Notes in Theoretical Computer Science. Roč. 299, 25 Dec (2013), s. 61-67. ISSN 1571-0661
Grant CEP: GA MŠMT(CZ) EE2.3.20.0256
Institucionální podpora: RVO:67179843
Klíčová slova: biological models * model annotation * systems biology * simulation * database
Kód oboru RIV: EH - Ekologie - společenstva

A Comprehensive Modeling Platform, that is, a general framework for public sharing, annotation, and visualization of domain-specific biological models, is presented. For a selected organism, the framework is instantiated as a web-based application which allows to capture several aspects of biological models represented as biochemical reaction networks or ordinary differential equations. The key feature of the instantiation for a given organism relies on mapping kinetic models to a precise textual and a schematic graphical representation of the related biological knowledge, thereby supporting the systems biological view of the modeled organism. Besides model repository and annotation, the platform includes basic model analysis features such as simulation and static analysis.
Trvalý link: http://hdl.handle.net/11104/0232382