Počet záznamů: 1
Influence of bacteria on colitis developing in SCID mice reconstituted with CD4+CD45RBhigh T cells and the changes of tight junctions (TJs) and a-defensine were detected in terminal ileum
- 1.0425991 - MBÚ 2014 PL eng A - Abstrakt
Štěpánková, Renata - Powrie, F. - Kofroňová, Olga - Kozáková, Hana - Hudcovic, Tomáš - Hrnčíř, Tomáš - Tlaskalová-Hogenová, Helena
Influence of bacteria on colitis developing in SCID mice reconstituted with CD4+CD45RBhigh T cells and the changes of tight junctions (TJs) and a-defensine were detected in terminal ileum.
Microbiology and Immunology of Mucosa. Varšava: Institute of Immunology and Experimental Therapy Polish Academy of Science, 2013. s. 47. ISBN 978-83-928488-3-7.
[Polish-Czech Probiotics Conference - Microbiology and Immunology of Mucosa 2013 /1./. 28.05.2013-31.05.2013, Kudowa Zdrój]
Grant CEP: GA ČR GA303/04/0849
Institucionální podpora: RVO:61388971
Klíčová slova: colitis
The transfer of CD4+CD45RBhigh subset of T cells isolated from spleen of immunocompetent BALB/c mice into conventional SCID mice (mice with severe combined immunodeficiency) leads to development of chronic intestinal inflammation. Altered tight junctions (TJs) mainly ZO-1 and claudin-1 proteins were detected in colitic mice in terminal ileum. Alpha defensine in Paneth cells was no present colitic mice. Structural changes of terminal ileum -TJs and alpha defensine are important feature of intestinal inflammation in transferring model of mouse colitis
Trvalý link: http://hdl.handle.net/11104/0231778
Počet záznamů: 1